efficacy of triptans in migraine menstrual
menstrual migraine affects approximately 50-60% of women who suffer from migraines, but knowledge about the role of hormones, particularly estrogen, is yet to be defined in a comprehensive manner. Researchers at Vanderbilt University School of Medicine in Nashville (USA) conducted a systematic review aimed to determine the role of hormones menstrual migraine. From the literature, we selected 643 articoli.L 'influence of estrogen in migraine is evident by the fact that women have an incidence of migraines three times more than men, and significant changes in the incidence of migraine in female reproductive function of the state. The menstrual migraine is generally more resistant to treatment, usually not associated with aura, is long lasting and, in general, involves a greater functional disability compared with attacks occurring at other times of the month. The genetic and biochemical evidence indicates a central and peripheral role of estrogen in the pathophysiology of menstrual migraine, with potential interactions with excitatory circuits, including serotonergic components. Although there is no evidence regarding the use of estrogen as a preventative treatment of menstrual migraine, serotonin receptor agonists (triptans) have a deep relief and may also have a preventive role. In conclusion: the epidemiological evidence, clinical and pathophysiological correlates estrogen migraine. Triptans appear to significantly alleviate the pain and can also be used as a preventive measure.
Brandes JL, JAMA 2006, 295: 1824-1830
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