Sildenafil may be useful in Crohn's disease
according to researchers at 'University College London, the underlying cause of Crohn's disease would be opposed to that previously supported. At the base, there would be an alteration of innate immunity, rather than a hyperactive immune system. Crohn's disease is a chronic inflammatory bowel disease characterized by ulcers in the intestine. E 'and is considered an autoimmune disease currently treated with immunosuppressants. British researchers, led by Anthony Segal, have instead found that people with Crohn's disease have a weak immune system and non-responsive, unable to easily repair the damage in the intestine. The direction of blood flow in damaged cells is substantially reduced and the authors believe that a drug like sildenafil (Viagra, Revatio) could be useful in patients with Crohn's disease, because of its effect of stimulating blood flow. The researchers compared the immune system of patients with Crohn's disease with that of healthy individuals with minor damage (eg skin abrasions) and found differences in the number of neutrophils produced by the body to repair the damage in the intestine and skin. Healthy people have more neutrophils than patients with Crohn's disease, showing that the immune response in people with Crohn's is damaged. E 'was also evaluated the inflammatory response to bacteria (Escherichia coli). Patients with Crohn's disease were unable to destroy bacteria that penetrate the intestinal wall, because of the weakness of the immune system.
Source: The Lancet, 2006
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