The effect of antidepressants in the homeostasis of glucose and insulin sensitivity
Researchers at Toronto University conducted a Medline search with the objective of evaluating the effect of antidepressant drugs glucose-insulin homeostasis. An analysis of the literature showed that serotonergic antidepressants such as fluoxetine, reduce hyperglycemia, normalize glucose homeostasis and increase insulin sensitivity, whereas some noradrenergic antidepressants such as desipramine, exert opposite effects. The dual mechanism of action of antidepressants such as duloxetine and venlafaxine do not appear to alter glucose homeostasis, whereas, for example, phenelzine, an MAOI, was associated with hypoglycemia and an increased rate of glucose disposal .
McIntyre RS et al, Export Opin Drug Saf 2006; 5: 157-168
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