Effects of Cannabis on neurodevelopmental
The developing brain is susceptible to the effects of exogenous cannabinoids both during the perinatal period (through the use of cannabis by the mother) and adolescence. Perinatal exposure data in animals and humans have shown an effect Cannabis on certain features, including: specific cognitive deficits, especially in visuospatial function, impulsivity, inattention and hyperactivity, symptoms of depression. Animal studies have shown that the systems of motor control, neuroendocrine function and nociception can be affected by cannabis. Fetal studies have shown that these effects are due to influences mediated by cannabinoids on neurotransmitter systems based on the dopamine and the opioids. Cannabinoids during adolescence produce deleterious effects on the cognitive system, symptoms of depression, schizophrenia and substance use disorders. Sex-specific differences were observed both in human studies than in those animals.
Sundram S et al, Hum Psychopharmacol 2006; 21: 245-254
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