Ou Acheter Jeff Hardy

varenicline, a drug for smoking cessation

Varenicline (Champix ) is a partial agonist of the nicotinic receptor alpha4-beta2. The effectiveness of varenicline has been evaluated in two placebo-controlled clinical trials in about 2000 smokers. These subjects were randomly assigned to receive varenicline 1mg twice a day, bupropion 150mg 2 times daily, or placebo for 12 weeks. The follow-up period was 40 weeks (without treatment). 44% of patients treated with varenicline stopped smoking at the end of the treatment period of 12 weeks, compared with 30% of patients who quit after taking bupropion and 18% of those treated with placebo.Dopo 1 year, patients who received varenicline were significantly more likely to remain smoke-free than patients who received bupropion or placebo. In a third study, patients were treated with varenicline for 12 weeks, and then were randomly assigned to either placebo or varenicline for another 12 weeks. These patients were followed for 28 weeks after treatment. 71% of subjects taking varenicline were smoke-free after 6 months compared to 50% on placebo.